[Retracted] si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway

Figure 6

The exosomes loaded with si-PDGFRβ exerted tumor inhibition effects on glioma in vivo. (a) Brain MRI was performed on the treated mice after four-week treatment to measure the volume of the transplanted tumor. The results showed that the exosomes loaded with si-PDGFRβ significantly inhibited the growth of gliomas. (b) In vivo bioluminescence, imaging showed that exosomes loaded with si-PDGFRβ had relatively high targeting ability. (c) H&E staining indicated that the si-PDGFRβ-Exo-treated group induced more necrotic cells than the PBS and Unload-Exo groups. TUNEL assay indicated that si-PDGFRβ-Exo induced apoptosis. (d) Immunoblot detection demonstrated that si-PDGFRβ-Exo significantly decreased p-PI3K, p-AKT, EZH2, and PDL1 proteins ( vs. PBS or Unloaded-Exo group).

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