Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue

Figure 1

Experimental design of this study. For the sham group rats, only their blood vessels were exposed, and no embolization coils were introduced. Rats in the XST, Dex, and XST+Dex groups were treated medically every day after MCAO surgery for 10 days. The mNSS of rats in each group were measured before surgery and on days 1, 2, 6, and 10 of treatment. On the 5th and 10th days of treatment, behavioral tests were performed in each group of rats, followed by the collection of hippocampal tissues. On the 10th day of treatment, the hippocampal tissues were collected from rats in each group after completing behavioral tests; then, hematoxylin and eosin (H&E) staining was performed to observe histopathological changes in these tissues.