Significance of a PTEN Mutational Status-Associated Gene Signature in the Progression and Prognosis of Endometrial Carcinoma

Figure 3

Identification of differentially expressed genes (DEGs) and construction of the PTEN mutational status-associated prognostic signature. (a) Heatmap showing the top 40 DEGs between the EC patients with and without PTEN mutation. (b) Volcano plot showing the DEGs between the EC patients with and without PTEN mutation. (c) LASSO coefficient profiles of the 84 DEGs with prognostic value. (d) Nine PTEN mutation prognostic genes obtained from LASSO regression based on 10-fold cross-validation and minimal criteria. (e–k) The relative expression levels of the seven prognostic genes (GDPD2, GRB7, KCNK9, MUC3A, MYT1, RPS6KA6, and TSPYL5) between the EC patients with and without PTEN mutation.

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