Review Article

Role of MicroRNAs in Cardiac Disease with Stroke in Pregnancy

Table 1

Management strategies of cardiac disease and stroke in pregnancy.

Hypertensive disorder of pregnancy (HDP)Ischemic heart disease in pregnancy (IHD)Vulvar heart disease in pregnancyStroke in pregnancy

Precounseling to avoid pregnancy until control of hypertension or during pregnancy advise following belowPrepregnant council to delay pregnancy after treatment of IHD. If unexpected pregnant, then the following managementPregnancy should be avoided in severe mitral and aortic valve disease. If unexpected pregnant, then the following managementPrecounseling to control hypertension who has a previous history of preeclampsia

Investigation
Urine test for proteinuria.Positive stress ECG, MRI, and exercise testing evidence for IHD and recommendation coronary angiography, if clinically indicated.Clinical and ECG knowledge are required sequentially for a pregnant woman to know the condition of valvular heart disease. The percutaneous valve intervention is the best treatment for those who are not responding to the medical therapy.MRI images are considered an optimal modality during pregnancy, in case of missing timely taken MRI, then angiography CT and also perfusion CT can be chosen as a guide for proper interventional therapies.
Ophthalmoscopic examination.
Blood values
USG

Risk factors
Hypertension, obesity, and family history of diabetesHypertension and preeclampsia are strongly associated with AMI.Rheumatic fever is a most commonPreeclampsia, eclampsia
Mechanical heart valves

Pregnancy management
Close follow-upClose follow-upClose follow-upClosely monitoring. Common drugs used: labetalol, atenolol, methyldopa, nifedipine, warfarin, and heparin (low molecular weight), and direct oral anticoagulants.
Medical therapy: Nifedipine, methyldopa, labetalol, and hydralazineMedical therapy: antiplatelet therapy, nitrates, beta-blockers, inotropes, and oxygen
Intervention: PCI and cardiac surgery
Medical therapy for heart failure or arrhythmias
Balloon valvuloplasty or surgical valve replacement

Delivery
Vaginal delivery with control of hypertensionNormal vaginal delivery unless cardiac and obstetrician indication. Continuous maternal cardiac monitoring. Continuous electronic fetal monitoring. Emergency cesarean section prior to cardiac surgery if needed.If possible, vaginal delivery is preferred. Cesarean section is chosen when there is risk to the mother or fetus. Early delivery for clinical and hemodynamic worsening.Vaginal delivery is the best approach if there is no obstetric contraindication.
Emergency cesarean section if required

Complication
Stroke, hypertension, and cardiac disease are responsible for the development of preeclampsia or eclampsia during pregnancy and also in postpartumCardiac arrest, heart failure, and ventricular tachycardiaPulmonary edema, atrial arrhythmias, stroke, and heart failureReversible cerebral vasoconstriction syndrome can cause both ischemic and hemorrhagic stroke and the risk of cerebral venous sinus thrombosis (CVST). Long-term disability

Follow-up
The utility of subclinical vascular measurements, such as cerebral or peripheral vasomotor reactivity, carotid intimal medial thickness, coronary calcification, or clinical and biochemical biomarkers, is needed to identify women with a history of preeclampsia at increased risk of future stroke.Maternal cardiac monitoring for at least 48 hours after deliveryHemodynamic monitoring at least 24 hours postpartumCounseling and cardiovascular screening of women who have a past history of preeclampsia. As well as correction of the other vascular risk factors.