[Retracted] Breast Cancer Exosome-Derived miR-425-5p Induces Cancer-Associated Fibroblast-Like Properties in Human Mammary Fibroblasts by TGFβ1/ROS Signaling Pathway

Figure 6

Exosomal miR-425-5p stimulated tumor growth in vivo. (a) Tumors in mice transplanted with miR-NC transfected MDA-MB-231 cells and miR-425-5p mimics/or inhibitors transfected MDA-MB-231 cells. (b) Growth curve of tumors in different groups. (c) Tumor weight in different groups. (d) Tumors in mice transplanted with miR-NC transfected CAFs and miR-425-5p mimics/or inhibitors transfected CAFs. (e) Growth curve of tumors in different groups. (f) Tumor weight in different groups. (g, h) IHC staining showed the expression of TGFβ1, α-SMA, vimentin, Ki67, and CXCL1 in different groups. Experimental data presented as . Experiment was repeated 3 times. compared with the MDA-MB-231 miR-NC/CAFs miR-NC group. ^## compared with the MDA-MB-231 mimics/CAF mimics group.

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