C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients

Table 2

Prediction value of 25(OH)D metabolites on the severity of CKD in RA patients.

CKD severity	Metabolites	Crudely analysis			Adjusted analysis
		OR (95% CI)			OR (95% CI)
Moderate	25(OH)D2	1.12 (0.99, 1.25)	3.73	0.053	1.11 (0.99, 1.25)	3.214	0.073
	25(OH)D3	0.86 (0.81, 0.92)	19.163	<0.001	0.87 (0.81, 0.93)	17.456	<0.001
	C3-epi-25(OH)D3	4.97 (2.70, 9.14)	26.518	<0.001	4.79 (2.59, 8.83)	25.18	<0.001
Severe	25(OH)D2	1.08 (0.91, 1.29)	0.786	0.375	1.09 (0.91, 1.31)	0.844	0.358
	25(OH)D3	0.72 (0.64, 0.82)	26.449	<0.001	0.72 (0.63, 0.82)	25.68	<0.001
	C3-epi-25(OH)D3	17.77 (6.04, 52.27)	42.078	<0.001	17.85 (5.97, 53.32)	41.005	<0.001

Note: Adjusted factors include age, sex, hsCRP, and RF. The results above were compared with the mild CKD severity. Of the 25(OH)D metabolites observed, C3-epi-25(OH)D had a better predictive value for both moderate CKD (, , ) and mild CKD (, ,).