Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer Immunity

Figure 7

Analysis of ANLN-related genes and pathway enrichment. (a) STRING protein network map of top 50 experimentally determined ANLN-binding proteins. Each colored nodes indicate one individual protein identified. (b) Expression correlation between ANLN and the representative genes (CKAP2L, KIF23, KIF14, RACGAP1, and DEPDC1) of the top ANLN-correlated genes in the TCGA database generated by the GEPIA2 tool. (c) Heatmap representation of the expression correlation between ANLN and CKAP2L, KIF23, KIF14, RACGAP1, and DEPDC1 in the individual cancer type of all TCGA tumors. (d) An intersection analysis of the ANLN-interacted (by STRING database) and ANLN-correlated (by GEPIA2) genes. RACGAP1 is the only intersected genes of the above two datasets. (e) KEGG pathway analysis based on the ANLN-interacted and ANLN-correlated genes.

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