Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Figure 4

CoV increases ROS in plasma cells. nPC and sPC were prepared and exposed to CoV (10 μg/ml) in the culture for 48 h. (a) The gated FACS histograms show ROS in plasma cells. (b) The bars show the mean fluorescence intensity (MFI) of ROS staining in plasma cells. (c) The heatmap shows positive correlation between plasma cell MFI and the CoV-induced plasma cell apoptosis (the data are presented in Figure 3). (d–f) Boxplots show levels of ROS, MDA, and SOD levels in plasma cells. (g) Scatter plots show negative correlation between SOD and ROS in sPCs. ACE2d: ACE2-deficient plasma cells. (ANOVA followed by Dunnett’s test), compared with group A. The data of boxplots are presented as median (IQR). Group labels of (b–f) are the same as those in (a). Each dot in boxplots presents data obtained from one sample. The group labels of (b–f) are the same as (a).

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