Research Article
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson’s Disease
Figure 6
SNX5 promotes ferroptosis in the PD cell model. (a) Infection of PC-12 cells by conventional siRNA and screening the infected fragment with the best knockdown effect by Western blotting. PC-12 cells were infected with SNX5 transfected fragments before being treated with 40 μM 6-OHDA for 24 h. The expression of TH and GPX4 was analyzed using Western blotting (b), and the effect of SNX5 knockdown on MDA (c), GSH/GSSG (d), and Fe2+(e) was detect by assay kit. Data were expressed as ; three independent replicates of the experiment ().
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