Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Containing Long Noncoding RNA NEAT1 Relieve Osteoarthritis

Figure 8

Schematic diagram of the mechanism by which NEAT1 affects OA progression. BMSC-EVs can deliver NEAT1 into chondrocytes where NEAT1 competitively binds to miR-122-5p and upregulates the expression of the miR-122-5p target Sesn2, thereby activating the Nrf2 pathway, promoting chondrocyte proliferation and autophagy while inhibiting their apoptosis, ultimately preventing the progression of OA.