Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway

<div>AS-IV treatment ameliorates bladder wall remodeling in pBOO rats. (a–d) Bladder wall sections of four groups were analyzed by morphology staining as indicated in panel. General structure (H&amp;E) (a), muscle tissue (<i>α</i>SMA) (b), apoptosis (Tunel, black arrow pointed to parts of positive nuclear) (c), and fibrosis (Col I and Col III) (d) staining indicated that pBOO induced bladder wall remodeling, and AS-IV treatment alleviated this progress.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway 

Figure 2 | Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway 