Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway

Figure 3

AS-IV treatment enhances the contractile force of detrusor in pBOO rats. (a–d) Contractile responses of bladder muscle strips from rats subjected to sham (violet), pBOO (red) followed by either control or low-dose AS-IV (greed)/high-dose AS-IV (blue) were determined by isometric tension testing in response to electrical field stimulation (a), carbachol (b), α, β-methyl-adenosine triphosphate (α, β-me ATP) (c), and potassium chloride (KCl) (d). (e) Protein level of mAChR M2 and M3 in bladder lysis. , , , pBOO vs. sham; ^#, ^##, ^###, AS-IV-treated groups vs. pBOO. Error bars show ±SEM.

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