ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts

Figure 3

ROS accumulation changed Ki67 expression pattern and decreased RhoA and AMGN expressions. (a) The outer enamel epithelium of SOD1 (-/-) mice exhibited the greatest proliferation capacity, followed by the metastatic proliferation zone, and the stellate reticulum cells had a relatively moderate proliferation ability. (b–d) The difference of expression of AMBN, AMGN, and RhoA between SOD1 (-/-) mice and SOD1 (+/+) mice. Scale bars: (a–d) 100 μm and 50 μm; , respectively.

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