ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts

<div>ROS-mediated activation of PI3K-AKT in cervical loop cell and reduction of RhoA/ROCK expression on ameloblasts instead of direct detriment to enamel matrix proteins. (a) The PI3K-AKT signaling pathway was activated by 10 <i>μ</i>M, 25 <i>μ</i>M, 50 <i>μ</i>M, and 100 <i>μ</i>M H<sub>2</sub>O<sub>2</sub> and elevated the expression of phosphorylated AKT. (b) The downregulation of RhoA-ROCK expression when treated with SOD1 siRNA. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts 

Figure 5 | ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts 