[Retracted] Leukemia Inhibitory Factor Facilitates Self-Renewal and Differentiation and Attenuates Oxidative Stress of BMSCs by Activating PI3K/AKT Signaling

Figure 6

LIF upregulation alleviates oxidative stress in hypoxic BMSCs through activating PI3K/Akt signaling. (a–d) Immunoblotting for SOD1, catalase, and GPx-3 activity in hypoxic BMSCs with LIF overexpression as well as PI3K/Akt signaling agonist 740Y-P or inhibitor LY294002. (e–j) Immunoblotting for PI3K, p-PI3K, AKT, p-AKT, and HIF-1α activity in hypoxic BMSCs with LIF overexpression as well as PI3K/Akt signaling agonist 740Y-P or inhibitor LY294002. (k–n) Immunofluorescent staining for LIF and LIFR in hypoxic BMSCs with LIF overexpression as well as PI3K/Akt signaling agonist 740Y-P or inhibitor LY294002. Bar, 20 μm.

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