OGG1 in the Kidney: Beyond Base Excision Repair

Figure 2

The role of OGG1 in regulation gene transcription in the promoter region. ROS oxidizes guanine in the DNA promoter region and recruits OGG1 to DNA promoter region, and OGG1 interacts with PARP1 and XRCC1 to remove 8-oxoG. At the same time, the G-quadruplex structure is opened up and the transcription factors NF-κB, VEGF, and ATG7 are recruited to activate downstream inflammatory, fibrosis, and autophagy pathways. Then, Polβ, PCNA, FEN1, and Ligase 3 work together to repair DNA double strands. ROS: reactive oxygen species; PARP1: polyADP-ribose polymerase 1; XRCC1: X-ray repair cross complementing 1; NF-κB: nuclear factor kappa-B; VEGF: vascular endothelial growth factor; ATG7: autophagy-related 7; Polβ: DNA polymeraseβ; PCNA: proliferating cell nuclear antigen; FEN1: flap structure-specific endonuclease 1.