OGG1 in the Kidney: Beyond Base Excision Repair

Figure 5

The role of OGG1 in kidney diseases. In kidney tumors, OGG1 induces DNA base excision repair and regulates autophagy to inhibit formation of kidney tumors. In acute kidney injury, OGG1 activates inflammation and induces oxidative stress to aggravate renal injury. In chronic kidney disease, OGG1 induces chronic inflammation and promotes fibrosis.