Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy

Figure 2

SPM attenuates the myocardial ultrastructural and histomorphological changes of DbCM mice. (a) Myocardial ultrastructure by electron microscopy (original magnifications ×2,000 or 5,000; or 5 μm). (b) Myocardial histomorphology by H&E staining (original magnification ×200; ), Masson’s trichrome (collagen deposition displayed in blue), and Sirius red staining (collagen fibers displayed in red; original magnification ×400; ). (c) Fibrotic area analysis. versus the CK group. ^# versus the DbCM group.

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