Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy

Figure 4

SPM reduces DbCM myocardial damage by regulating lipid metabolism and amino acid metabolism pathways. (a) The heat map showed the DEGs related to lipid metabolism pathway in DbCM/CK and SPM/DbCM. (b) The heat map showed the DEGs related to amino acid metabolism pathway in DbCM/CK and SPM/DbCM. (c) The heat map showed the coexpressed genes related to metabolic pathway in the CK, DbCM, and SPM groups. Red color shows the genes with significantly elevated transcription levels, and green color shows the genes with significantly reduced transcription levels.

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