Research Article

Increased PD-L1 Restricts Liver Injury in Nonalcoholic Fatty Liver Disease

Figure 8

PD-L1 limits liver injury in NAFLD models. (a and b) Western blot determined the effect of siRNA against PD-L1. (c) After PD-L1 knockdown, mRNA expression levels of markers of T cell activation measured by qRT-PCR. (d and e) Hepatocyte injury was evaluated by the Tunel assay and ALT/AST measurement. (f) Graph illustrating that both ROS/ZNF24 pathway activation and UBE2I-mediated ZNF24 sumoylation suppression induced by FFA promoted PD-L1 expression. , .
(a)
(b)
(c)
(d)
(e)
(f)