[Retracted] Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets

Figure 2

Safety assessment of cRGD-platelet@MnO/MSN@PPARα/LXRα nanoparticles. (a) CCK-8 was used to detect the proliferation of THP-1 cells and foam cells treated with different nanoparticles. (b) Flow cytometry assay was used to detect the apoptosis of foam cells treated with different nanoparticles. (c) The routine blood, liver, and kidney function were detected by ELISA after treatment with different concentrations of nanoparticles. (d) The contents of ALT, AST, BUN, and CREA in serum injected with different concentrations of nanoparticles. (e) H&E staining was utilized to detect the status of the tissue in different organs treated with different concentrations of nanoparticles. (f, g) TUNEL and PCNA immunohistochemistry were used to detect the changes in apoptosis and proliferation after treatment with nanoparticles at different concentrations. Data are shown as the . for (b) and (e)–(g); for (a), (c), and (d).

(a)

(b)

(c)

(d)

(e)

(f)

(g)