[Retracted] Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets

Figure 4

Diagnostic and therapeutic evaluation of cRGD-platelet@MnO/MSN@PPARα/LXRα nanoparticles in vitro. (a) Cell viability was detected by CCK-8 after treatment with different nanoparticles. (b, c) Flow cytometry and TUNEL assays were utilized to determine the apoptosis of cells treated with cRGD-platelet@MnO/MSN@PPARα/LXRα. (d) The level of ROS was detected by DCFH-DA immunofluorescent assay. (e) The levels of SOD, MDA, and NOX were evaluated using commercial assay kits. (f) ELISA analysis was used to detect the contents of IL-10 and TGF-β after treatment with cRGD-platelet@MnO/MSN@PPARα/LXRα. (g) The expression changes of ABCA1 and LXRα were determined by western blot after treatment with the cRGD-platelet@MnO/MSN@PPARα/LXRα. Data are shown as the , vs. control. for (c) and (d); for (a), (b), (e), (f), and (g).

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