Hypothermia Protects against Ischemic Stroke through Peroxisome-Proliferator-Activated-Receptor Gamma

<div>Hypothermia inhibits activation of microglia/macrophage and neuroinflammation after I/R in mice. (a) Representative immunofluorescence staining of Iba-1+ in the ischemic region for every group. Scale bar: 50 <i>μ</i>m, magnification: 400×. (b) Quantification analyses of the percentage of Iba-1 positive cells in total cells. (c) Representative western blotting analysis of Iba-1 in the ischemic region for every group. GAPDH was used as a loading control. (d) Quantifications of the expression of Iba-1. (e) qRT-PCR analysis of M1 activated microglia/macrophage markers in the ipsilateral brain tissues for every group. (f) qRT-PCR analysis of M2 activated microglia/macrophage markers in the ipsilateral brain tissues for every group. All gene expressions were normalized to GAPDH. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Hypothermia Protects against Ischemic Stroke through Peroxisome-Proliferator-Activated-Receptor Gamma 