Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 1

Cytotoxic activities of doxazosin, carvedilol, and curcumin on HepG2 cells. (a) Doxazosin reduces cell viability timeline and dose dependent in the HepG2 cell line. (b) Carvedilol induces proliferation of HepG2 cells at 24 h, while at 48 h, carvedilol is cytotoxic at low concentrations. (c) Curcumin protects HepG2 cells against the induced cytotoxicity for doxazosin. (d) Curcumin pretreatment-maintained viability in HepG2 cells treated with carvedilol. (e) Curcumin hormesis in HepG2 cells, the viability was analyzed by the MTT assay for 24 h and is presented relative to the activity at the start of the experiment in each case. The results are from three independent experiments. Data are ; , , , and versus the control.

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