Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 2

Morphological effects on the monolayer of HepG2 cells exposed to α- and β-adrenoblockers. The arrows indicate the cells’ main morphological changes as alteration of the monolayer, decreased cell interaction, aggregates of eosinophilic cells, and balonization. Curcumin protects the integrity of the monolayer during an interaction with proven antifibrotic drugs. Curcumin decreases the amount of cell death, maintains the integrity of the monolayer, increases the interaction between cells, reduces cell aggregates, and decreases balonization (arrow). Treatments for 24 h were visualized by hematoxylin and eosin staining taken at 200x of magnification.