Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 3

Ultrastructural effects of doxazosin and carvedilol on HepG2 cells. Black arrow: irregular cell surface with folds of the cell membrane. Yellow arrow: cell contraction with the formation of possible apoptotic bodies followed by fragmentation. Red arrow: balonization resulting in separation of neighboring cells. Curcumin reduces the morphological variations related to cell damage caused by α- and β-adrenoceptor blocking drugs. Cell morphology shows normal villi and intercellular junctions (blue arrow), without possible apoptotic bodies formation in HepG2 cells. Treatments for 24 h were visualized under SEM (5 μM scale bar).