Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 5

Curcumin protects HepG2 cells from the possible proapoptotic effect of doxazosin and carvedilol. HepG2 cells treated with doxazosin and carvedilol showed morphological changes characteristic of apoptosis: nucleus fragmentation (red arrow) and formation of possible apoptotic bodies (blue arrow). However, the pretreatment with curcumin decreases damage in the cell line compared to the control (untreated cells), which was stained bright green. Treatments for 24 h were visualized by acridine orange staining (at 200x of magnification).