Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

<div>RT-qPCR analysis for <i>Bcl</i>-2 mRNA expression, <i>Bax</i> mRNA expression, and the Ratio of <i>Bcl-2/Bax</i> after treatment with doxazosin and carvedilol at 24 h. (a) Doxazosin upregulated the proapoptotic gene <i>Bax</i>, over the antiapoptotic, <i>Bcl</i>-2, with the doses of doxazosin treatment mainly at 10 and 25 <i>μ</i>M. Interestingly, the <i>Bcl-2/Bax</i> expression ratio increased with the treatment curcumin. (b) Carvedilol represents the downregulation of <i>Bcl</i>-2 and upregulation of <i>Bax</i>. The graphic shows the <i>Bcl-2/Bax</i> expression ratio with a value lower than 1. Curcumin pretreatment regulates the propoptotic expression of <i>Bax</i>, and the graphic shows the <i>Bcl-2/Bax</i> expression ratio with a value higher than 1. The results are from three independent experiments. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells 