Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 8

RT-qPCR analysis for Nrf2, Keap1, HO-1, and SOD mRNA expressions after treatment with doxazosin at 24 h in the presence and absence of curcumin. The mRNA expression of Nrf2 were increased by doxazosin treatment (a,e) in the presence and absence of curcumin followed by increase in Keap1 expression compared to the control group (b,f). The increase of Nrf2 in cells treated with doxazosin caused the increased of HO-1 and SOD (c,d) while the effect of cotreatment with curcumin regulated the expression of these genes (g,h), possibly due to the control of the oxidative stress generated. The results are from three independent experiments. Data are ; , , , and versus the control.

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