Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells

Figure 9

RT-qPCR analysis for Nrf2, Keap1, HO-1, and SOD mRNA expressions after treatment with carvedilol at 24 h. Carvedilol shows mRNA expression levels of Nrf2 upregulated compared to the control with the dose 25 μM and a decrease in Keap1 compared to the control group in the presence and absence of curcumin (a,b,e,f). Curcumin pretreatment resulted in the activation of the Nrf2 gene and as result increased the antioxidant gene expression of HO-1 and SOD after the treatment (c,d,g,h). Data are expressed as the (). The results are from three independent experiments. Data are ; , , , and versus the control.

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