Research Article

ProNGF/NGF Modulates Autophagy and Apoptosis through PI3K/Akt/mTOR and ERK Signaling Pathways following Cerebral Ischemia-Reperfusion in Rats

Table 1

Modified neurological severity score point.

Motor tests

 Raising rat by tail3
  Flexion of the forelimb1
  Flexion of the hindlimb1
  Head moved >10°to the vertical axis within 30 s1
 Placing the rat on the floor (normal = 0; maximum = 3)3
  Normal walk0
  Inability to walk straight1
  Circling toward the paretic side2
  Falls down to the paretic side3
Sensory tests2
 Placing test (visual and tactile tests)1
 Proprioceptive test (deep sensation, pushing the paw against the table edge to stimulate limb muscles)1
Beam balance tests (normal = 0; maximum = 6)
 Balances with steady posture0
 Grasps the side of the beam1
 Hugs the beam and 1 limb falls down from the beam2
 Hugs the beam and 2 limbs fall down from the beam, or spins on the beam (>60 s)3
 Attempts to balance on the beam but falls off (>40 s)4
 Attempts to balance on the beam but falls off (>20 s)5
 Falls off; no attempt to balance or hang on to the beam (<20 s)6
Reflex absence and abnormal movements4
 Pinna reflex (head shake when the auditory meatus is touched)1
 Corneal reflex (eye blink when the cornea is lightly touched with cotton)1
 Startle reflex (motor response to a brief noise from snapping a clipboard paper)1
 Seizures, myoclonus, myodystony1
Maximum points18

One point is awarded for inability to perform the tasks or for the lack of a tested reflex: 13–18: severe injury; 7–12: moderate injury; 1–6: mild injury.