Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway

Figure 2

GDC and baicalin ameliorated renal function and disorder of renal lipid metabolism in 18-week-old db/db mice. (a and b) Administration of (a) GDC and (b) baicalin reduced the body weight of diabetic nephropathy mice. (c) Serum GLU, (d) albuminuria, (e) BUN, (f) CREA, (g) serum TC, (h) TG, (i) HDL-C, and (j) LDL-C of mice treated with GDC or valsartan were measured at the 18th week. (k) Serum GLU, (l) albuminuria, (m) BUN, (n) CREA, (o) Serum TC, (p) TG, (q) HDL-C, and (r) LDL-C of mice treated with baicalin were measured at the 18th week. ^a1.5 g·kg⁻¹day⁻¹, ^b3.0 g·kg⁻¹day⁻¹, , , and .

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