[Retracted] Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling

Figure 3

Effect of GDN on p62/Nrf2/HO-1 signaling pathway. (a-c) Activation of Nrf2 signaling by GDN in LPS-stimulated macrophages. (d-f) Activation of Nrf2 signaling by GDN in normal macrophages. (g-k) GDN activates p62/Nrf2/HO-1 signaling in MH7A cells in a time-dependent manner. (l-m) GDN caused Nrf2 activation in RASFs. Cells were seeded into 6 well plates and then treated with GDN for different time and different concentration. mRNA and protein were detected by Q-PCR and western blotting, respectively. Values of , , and were declared statistically significant vs control group; , , and were declared statistically significant vs LPS group.

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