[Retracted] Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling

Figure 5

Effect of GDN on collagen-induced arthritis in DBA/1 mice. (a) Procedure of collagen-induced arthritis and time point of treatment with GDN in CIA mice. (b) Images of representative paws from different groups. (c-f) Incidence of arthritis, hind paw swelling, arthritis score, and body weight in every group. (g) Micro-CT images of representative paws from different groups. (h-i) Influence of GDN on bone erosion and bone volume. (j-m) Inflammatory cytokines mRNA levels in every group. Values of , , and were declared statistically significant vs ctrl group; , , and were declared statistically significant vs model group. After the second immunization with collagen until the terminal of experiment, mice were administered intraperitoneally with GDN 2.5, 5 mg/kg every day and intragastrically 10 mg/kg MTX every three days. Incidence of arthritis, hind paw swelling, arthritis score, and body weight in every group were recorded every two days.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)