Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells

Figure 5

Effects of DEAC (a), CM (b), and AMB (c) on iNOS expression in LPS-stimulated BV-2 cells. Cells were pretreated with DEAC (100 μg/mL), CM (50 and 100 μg/mL), or AMB (25 μg/mL) for 1 h and incubated with LPS (0.5 μg/mL) for additional 24 h. Two-way ANOVA in graphs (a) and (c), and one-way ANOVA for graph (b), followed by Bonferroni posttest. ^# vs. negative control (0.1% DMSO, drug vehicle), ; vs. LPS group, /group.

(a)

(b)

(c)