Macrophage Infiltration Reduces Neurodegeneration and Improves Stroke Recovery after Delayed Recanalization in Rats

Figure 4

Angiogenesis after delayed recanalization. (a) Representative image of microvessels stained with lectin in sham, rMCAO, and pMCAO groups. (b) Representative immunohistochemical staining for lectin, PDGFRβ, and CD34. Angiogenesis is depicted by cells expressing colocalization of PDGFRβ and CD34 markers around the endothelial cells. (c) Representative immunohistochemical staining for fibronectin, PDGFRβ, and CD34; BBB leakage is depicted by fibronectin expression around microvessels. (d) Quantification of microvessel area in each group. (e–g) Quantification of CD34-positive cells, pericyte coverage, and BBB leakage in each group. Error bars represent the . and vs. sham group; ^# and ^## vs. rMCAO group ().

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