Artemisinin Alleviates Cerebral Ischemia/Reperfusion-Induced Oxidative Damage via Regulating PHB2-Mediated Autophagy in the Human Neuroblastoma SH-SY5Y Cell Line

Figure 3

ART treatment decreased the OGD/R-induced ROS levels (a) and MDA content (b) and increased the GSH content (c) and SOD activity (d). ART alleviated the OGD/R-induced mitochondrial damage. ART alleviated OGD/R-induced depolarization of mitochondrial membrane potential (MMP). JC-1 staining was performed to assess MMP (e). Red fluorescence to green fluorescence was analyzed to evaluate the ratio of mitochondrial depolarization (f). ART treatment reduced the production of mtROS induced by OGD/R (g). Values were expressed as (). . vs. control group, vs. control group; ^# vs. OGD/R group, ^## vs. OGD/R group, and ^### vs. OGD/R group.

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