Artemisinin Alleviates Cerebral Ischemia/Reperfusion-Induced Oxidative Damage via Regulating PHB2-Mediated Autophagy in the Human Neuroblastoma SH-SY5Y Cell Line

Figure 5

Silencing PHB2 caused oxidative stress damage (a–d) and leaded to depolarization of MMP (i, j). Silencing PHB2 eliminated the protection of ART against OGD/R-induced oxidative stress in SH-SY5Y cells (e–h) and eliminated the protection of MMP (k, l). Silencing PHB2 eliminated the protective effect of ART on the viability of SH-SY5Y cells (m). Values were expressed as (). . vs. control group, vs. control group, and vs. control group; ^## vs. OGD/R group, ^### vs. OGD/R group; ^$ vs. ART+OGD/R group, ^$$ vs. ART+OGD/R group, and ^$$$ vs. ART+OGD/R group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)