The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity

Figure 1

MiR-377 is highly expressed in myocardial tissues of mice with CLP-induced sepsis. (a) Evaluation of cardiomyocyte hypertrophy in CLP-induced septic mice by echocardiography and ventricular body mass ratio (), compared with sham-operated mice. (b) HE staining of myocardial tissues of mice in sham-operated mice and CLP-induced septic mice group. (c) Myocardial tissue morphology of mice in sham-operated mice and CLP-induced septic mice, as observed by transmission electron microscope. (d) The expression level of miR-377 in the myocardial tissues in sham-operated mice and CLP-induced septic mice, as measured by qRT-PCR. compared with sham-operated mice. (e) The level of inflammatory factors and serum myocardial enzyme indexes of myocardial tissues in sham-operated mice and CLP-induced septic mice, as examined by ELISA. compared with sham-operated mice. Measurement data were showed as . Data of two-group were analyzed by unpaired -test.

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