The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity

Figure 4

MiR-377 modulated CaN activity by restricting Rcan2 (). (a) The mRNA level of Rcan2 and CaN in hypertrophic myocardial tissues of mice, as examined by qRT-PCR. (b) The protein expression of Rcan2 and CaN in hypertrophic myocardial tissues of mice, as measured by Western blot. compared with the oe-NC group. # compared with the oe-Rcan2 group. & compared with the si-NC group. @ compared with the si-Rcan2 group. Measurement data were represented as . Comparisons between multiple groups were performed by one-way ANOVA, followed by Tukey’s posthoc test. Above experiments were repeated in triplicate. , mice in each group.

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