No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study
Table 1
General characteristic of the study subjects according to SUA concentrations.
Quartiles of SUA (mg/dl)
Q1
Q2
Q3
Q4
N
2085
2106
2101
2137
Age
60.4 (7.6)
60.9 (7.4)
61.9 (7.8)
63.7 (8.0)
<0.001
Sex (female)
56.2
55.9
56.0
56.2
0.99
Education (≤6/7-9/10-12≥13)
29.1/38.8/23.0/9.1
28.7/36.8/24.8/9.7
28.0/34.9/24.9/12.3
30.7/34.2/22.8/12.4
<0.001
Waist circumference (cm)
78.2 (8.3)
79.7 (8.5)
80.4 (8.7)
81.9 (8.7)
<0.001
Body mass index (kg/m2)
22.6 (2.7)
23.1 (2.8)
23.5 (2.8)
24.0 (2.9)
<0.001
Fasting blood glucose (mmol/l)
5.86 (1.85)
5.70 (1.23)
5.76 (1.20)
5.83 (1.18)
<0.001
Triglyceride (mmol/l)
1.05 (0.55)
1.14 (0.60)
1.24 (0.84)
1.42 (0.85)
<0.001
Total cholesterol (mmol/)
5.00 (0.93)
5.07 (0.95)
5.13 (0.92)
5.20 (0.98)
<0.001
HDL (mmol/l)
1.51 (0.41)
1.48 (0.44)
1.45 (0.38)
1.39 (0.39)
<0.001
LDL (mmol/l)
2.93 (0.77)
2.99 (0.78)
3.04 (0.77)
3.11 (0.84)
<0.001
Alanine aminotransferase (U/l)
20.6 (24.0)
20.9 (12.1)
21.2 (10.8)
22.9 (16.0)
<0.001
Aspartate aminotransferase (U/l)
23.3 (14.3)
23.5 (10.0)
23.5 (7.7)
25.00 (11.5)
<0.001
Creatinine (μmol/l)
75.5 (19.9)
77.4 (17.3)
80.2 (17.8)
87.4 (30.0)
<0.001
Urea nitrogen (μmol/l)
5.00 (1.42)
5.08 (1.40)
5.21 (1.41)
5.56 (1.74)
<0.001
Systolic blood pressure (mmHg)
125.1 (17.6)
125.6 (18.3)
127.2 (18.2)
129.3 (18.4)
<0.001
Diastolic blood pressure (mmHg)
75.9 (10.4)
75.6 (10.7)
76.1 (10.6)
76.6 (10.8)
0.02
Smoking (current/quit/never)
18.7/9.7/71.5
18.0/9.6/72.5
16.1/12.0/71.9
14.7/11.9/73.4
0.001
Drinking (current/quit/never)
19.0/6.0/74.9
19.3/5.0/75.7
19.3/5.1/75.6
17.6/5.3/77.2
0.49
Physical activity (yes/no)
90.3/9.7
90.8/9.2
91.2/8.8
89.9/10.0
0.55
History of hypertension (%)
22.2
26.1
33.0
45.3
<0.001
History of coronary heart disease (%)
10.1
11.1
14.1
16.7
<0.001
Diabetes (%)
12.8
11.8
13.6
15.6
0.002
The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <4.47, ≥4.47, ≥5.23, and ≥6.10 mg/dl, respectively, and in female <3.53, ≥3.53, ≥4.15, and ≥4.84 mg/ml, respectively.
