No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study
Table 2
Adjusted odds ratios and 95% confidence intervals for incident NAFLD by SUA quartiles.
Quartiles of serum uric acid (mg/dl)
for trend
Q1
Q2
Q3
Q4
Total
Univariate model
Reference
1.44 (1.24, 1.69)
1.78 (1.52, 2.06)
2.27 (1.96, 2.64)
<0.001
Age and gender, adjusted
Reference
1.45 (1.24, 1.70)
1.79 (1.54, 2.08)
2.32 (2.00, 2.70)
<0.001
Multivariate model 1a
Reference
1.32 (1.12, 1.56)
1.44 (1.23, 1.69)
1.72 (1.46, 2.01)
<0.001
Multivariate model 2b
Reference
1.31 (1.11, 1.55)
1.43 (1.22, 1.69)
1.71 (1.45, 2.01)
<0.001
Male
Univariate model
Reference
1.35 (1.05, 1.73)
1.45 (1.14, 1.86)
2.04 (1.61, 2.58)
<0.001
Age, adjusted
Reference
1.35 (1.05, 1.73)
1.46 (1.14, 1.86)
2.05 (1.61, 2.60)
<0.001
Multivariate model 1a
Reference
1.27 (0.98, 1.64)
1.22 (0.94, 1.57)
1.64 (1.28, 2.10)
<0.001
Multivariate model 2b
Reference
1.27 (0.98, 1.64)
1.22 (0.94, 1.58)
1.63 (1.26, 2.11)
<0.001
Female
Univariate model
Reference
1.52 (1.24, 1.85)
2.00 (1.65, 2.43)
2.47 (2.04, 2.99)
<0.001
Age, adjusted
Reference
1.52 (1.25, 1.86)
2.02 (1.67, 2.46)
2.54 (2.09, 3.08)
<0.001
Multivariate model 1a
Reference
1.36 (1.10, 1.68)
1.60 (1.30, 1.97)
1.78 (1.44, 2.19)
<0.001
Multivariate model 2b
Reference
1.35 (1.09, 1.67)
1.59 (1.29, 1.96)
1.76 (1.42, 2.19)
<0.001
Normal-weight persons
Univariate model
Reference
1.49 (1.17, 1.90)
1.76 (1.39, 2.24)
2.20 (1.74, 2.77)
<0.001
Age and gender, adjusted
Reference
1.49 (1.17, 1.91)
1.77 (1.39, 2.25)
2.24 (1.77, 2.83)
<0.001
Multivariate model 1a
Reference
1.49 (1.17, 1.91)
1.77 (1.39, 2.24)
2.24 (1.77, 2.83)
<0.001
Multivariate model 2b
Reference
1.50 (1.17, 1.93)
1.80 (1.41, 2.29)
2.23 (1.75, 2.85)
<0.001
Overweight/obese persons
Univariate model
Reference
1.13 (0.92, 1.38)
1.17 (0.95, 1.43)
1.53 (1.26, 1.87)
<0.001
Age and gender, adjusted
Reference
1.13 (0.92, 1.39)
1.21 (0.98, 1.48)
1.63 (1.33, 2.00)
<0.001
Multivariate model 1a
Reference
1.14 (0.92, 1.40)
1.20 (0.98, 1.48)
1.63 (1.32, 2.00)
<0.001
Multivariate model 2b
Reference
1.10 (0.90, 1.36)
1.15 (0.93, 1.42)
1.56 (1.25, 1.93)
<0.001
The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <4.47, ≥4.47, ≥5.23, and ≥6.10 mg/dl, respectively, and in female <3.53, ≥3.53, ≥4.15, and ≥4.84 mg/ml, respectively. aAdjusted for the age (continuous), sex (male and female), BMI (continuous) plus smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), and physical activity (yes/no). In analysis of men and women, adjusted for age (continuous), BMI (continuous), smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), and physical activity (yes/no). bAdjusted for the same set of variables in model 1 plus prevalence (yes/no) of CHD, hypertension, diabetes, ALT concentration (continuous), Cre concentration (continuous), and FPG concentration (continuous).
