No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study

Table 3

Association between SUA levels and elevated levels of serum ALT, GGT, APRI, or FIB4.

UA	Unadjusted mean difference in ALT	Adjusted^a mean difference in ALT	Unadjusted mean difference in GGT	Adjusted^a mean difference in GGT	Unadjusted mean difference in APRI	Adjusted^a mean difference in APRI	Unadjusted mean difference in FIB4	Adjusted^b mean difference in FIB4
Q1	0	0	0	0	0	0	0	0
Q2	2.26 (0.68, 3.84)	2.65 (1.05, 4.25)	5.15 (1.49, 8.82)	5.85 (2.09, 9.62)	0.02 (-0.00, 0.04)	0.02 (-0.00, 0.04)	0.02 (-0.09, 0.14)	-0.01 (-0.13, 0.11)
Q3	2.05 (0.48, 3.62)	2.63 (1.02, 4.24)	8.29 (4.64, 11.95)	8.75 (4.95, 12.55)	0.03 (0.01, 0.06)	0.04 (0.01, 0.06)	0.15 (0.04, 0.27)	0.13 (0.01, 0.25)
Q4	3.74 (2.16, 5.32)	4.53 (2.89, 6.18)	11.49 (7.82, 15.16)	12.48 (8.61, 16.35)	0.05 (0.03, 0.07)	0.05 (0.03, 0.07)	0.15 (0.04, 0.27)	0.13 (0.01, 0.25)

The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <5.26, ≥5.26, ≥6.08, and ≥7.16, respectively, and in female <4.27, ≥4.27, ≥4.99, and ≥5.76, respectively. ^aAdjusted for sex (male and female), BMI (continuous) plus smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), physical activity (yes/no), Cre concentration (continuous), FPG concentration (continuous), prevalence of hypertension, CHD and diabetes (yes/no). ^bAdjusted for the age (continuous) plus variables in model ^b.