No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study

Table 4

Association between SUA and elevated levels of serum ALT, GGT, APRI, or FIB 4 among NAFLD.

Quartiles of SUA	Elevated ALT (%)	Adjusted^a OR of elevated^c ALT	Elevated GGT (%)	Adjusted^a OR of elevated^c GGT	Elevated APRI (%)	Adjusted^a OR of elevated^c APRI	Elevated FIB 4 (%)	Adjusted^b OR of elevated^c FIB 4
Q1	28.37	Reference	10.26	Reference	6.04	Reference	11.07	Reference
Q2	30.10	1.08 (0.81, 1.45)	13.86	1.46 (0.99, 2.17)	7.72	1.43 (0.86, 2.37)	10.89	1.04 (0.69, 1.58)
Q3	31.00	1.17 (0.87, 1.57)	15.80	1.74 (1.18, 2.57)	9.20	1.71 (1.05, 2.81)	13.00	1.31 (0.87, 1.95)
Q4	35.64	1.57 (1.17, 2.11)	20.40	2.45 (1.67, 3.59)	14.65	2.92 (1.83, 4.67)	16.24	1.62 (1.09, 2.41)
Odds ratio per unit (mg/dl) increase in SUA
All persons	N/A	1.14 (1.05, 1.24)	N/A	1.27 (1.15, 1.40)	N/A	1.32 (1.18, 1.48)	N/A	1.17 (1.05, 1.29)
Male	N/A	1.19 (1.03, 1.39)	N/A	1.26 (1.06, 1.50)	N/A	1.19 (1.01, 1.40)	N/A	1.12 (0.98, 1.29)
Female	N/A	1.13 (1.02, 1.25)	N/A	1.31 (1.15, 1.48)	N/A	1.47 (1.25, 1.74)	N/A	1.23 (1.05, 1.44)
Normal BMI	N/A	1.17 (1.02, 1.36)	N/A	1.33 (1.14, 1.57)	N/A	1.42 (1.16, 1.73)	N/A	1.22 (0.98, 1.51)
Over BMI	N/A	1.15 (1.06, 1.25)	N/A	1.28 (1.15, 1.40)	N/A	1.33 (1.18, 1.49)	N/A	1.16 (1.03, 1.30)

The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <5.26, ≥5.26, ≥6.08, and ≥7.16, respectively, and in female <4.29, ≥4.29, ≥5, and ≥5.78, respectively. Abbreviation: N/A: not applicable. ^aAdjusted for the age (continuous), sex (male and female), BMI (continuous) plus smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), physical activity (yes/no), Cre concentration (continuous), FPG concentration (continuous), and prevalence of hypertension, CHD, and diabetes (yes/no). ^bAdjusted for the same multivariable of model ^a without age. ^cAn elevated ALT was a  U/l for male and >19 U/l for female; an elevated GGT level was a  U/l for male and >33 U/l for female; an elevated APRI level was >0.5 for both male and female, and elevated FIB-4 level was >2.67 for both male and female.