Upregulated IGFBP3 with Aging Is Involved in Modulating Apoptosis, Oxidative Stress, and Fibrosis: A Target of Age-Related Erectile Dysfunction

Figure 10

Potential mechanisms by which IGFBP3 participates in age-related ED. The expression of IGFBP3 increases with aging. Downregulation of IGFBP3 with siRNA in CCSMCs enhances cell proliferation while reducing apoptosis, fibrosis, and OS, as determined by downregulation of Bax, collagen I, ROS, and MDA and upregulation of Bcl-2, MMP9, and SOD.