AKG Attenuates Cerebral Ischemia-Reperfusion Injury through c-Fos/IL-10/Stat3 Signaling Pathway

Figure 2

AKG therapy reduced nerve injury and brain cell death in MCAO mice. (a) Hematoxylin and eosin staining experiment (). Scale bar, 100 μm. (b) Nissl staining assay (). Scale bar, 100 μm. (c) TUNEL assay () (TUNEL, green; DAPI, blue) (). Scale bar, 100 μm. (d and e) The number of Nissl-positive neurons and TUNEL-positive cells was calculated. (f and g) BAX and BCL-2 mRNA levels were determined by RT-qPCR (). and versus the sham group and ^# and ^## versus the MCAO group.