CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross-Sectional and Intervention Studies In Vivo and In Vitro

Table 1

Main clinical features in the study population.

Variable	NGT	IGT	nT2DM
Age (yr)
Sex (M/F)	168 (82/86)	168 (81/87)	288 (147/141)
BMI (kg/m^2)			^▲
FAT (%)			^▲▲
WHR
SBP (mmHg)			^▲
DBP (mmHg)			^▲▲
TC (mmol/L)			^▲▲
TG (mmol/L)	1.32 (0.91-1.79)	1.90 (1.47-2.47)	2.01 (1.73-2.33)^▲
HDL-C (mmol/L)			^▲▲
LDL-C (mmol/L)			^▲▲
FFAs (μmol/L)	0.43 (0.36-0.57)	0.54 (0.46-0.69)	0.66 (0.59-0.73)^▲▲
HbA1c (%)			^▲▲
FBG (mmol/L)			^▲▲
2 h-BG (mmol/L)			^▲▲
FIns (mU/L)	8.59 (7.85-9.18)	9.23 (8.18-10.5)	12.1 (9.60-14.3)^▲▲
2 h-Ins (mU/L)	40.9 (37.7-46.9)	58.5 (50.8-65.2)	53.8 (45.7-63.9)^▲▲
AUCg			^▲▲
AUCi			^▲▲
HOMA-IR	1.93 (1.73-2.11)	2.37 (2.08-2.81)	3.77 (2.94-4.56)^▲▲
HOMA-β	109.7 (93.2-129.5)	77.4 (67.3-90.3)	67.4 (52.0-79.7)^▲▲
CTRP7 (μg/L)	111.8 (86.7-147.7)	133.0 (112.9-177.9)	196.4 (168.1-254.7)^▲▲
Adiponectin (μg/mL)	9.86 (6.49-16.2)	7.01 (5.62-12.6)	5.24 (3.18-8.74)^▲▲

BMI: body mass index; FAT (%): the percentage of fat in vivo; WHR: waist-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; FFAs: free fatty acid; HbA1c: hemoglobin A1c; FBG: fasting blood glucose; 2 h-BG: 2 h postglucose load blood glucose; FIns: fasting plasma insulin; 2 h-Ins: 2 h postglucose load blood insulin; AUCg: area under curve of glucose during OGTT; AUCi: area under curve of insulin during OGTT; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-β: an index of β-cell functions; values are or median (interquartile range). , vs. NGT; ^▲, ^▲▲ vs. IGT.