Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice

Figure 1

Transplanted MSCs were located at peripheral organs and had no obvious side effects. (a) Experimental time course for CLP, MSCs transplantation, and behavioral tests. (b) The survival of each group during 0-25 days after CLP surgery (Sham+NS , Sham+MSC , CLP + NS , CLP + MSC ; Log-rank (Mantel-Cox) test, ); (c) The body weight recovery of each group during experimental phases (Sham+NS , Sham+MSC , CLP + NS , CLP + MSC ; two-way ANOVA followed by multiple comparison tests); (d) Fluorescent signal was detected in peripheral organs (lung, spleen, liver) at 6 h, 24 h, and 72 h after CLP surgery ( for each group/time point). Sham+NS: mice received laparotomy and tail vein injection of normal saline; Sham+MSC: mice received laparotomy and tail vein injection of MSCs; CLP + NS: mice received CLP surgery and tail vein injection of normal saline CLP + MSC: mice received CLP surgery and tail vein injection of MSCs.

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