Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice

Figure 2

MSCs transplantation mitigated cognitive impairment of sepsis survival mice are as follows: (a) total distance and time in center zone of open field test on the 10^th day after CLP surgery (One-way ANOVA followed by multiple comparison tests, for each group); (b) preference index for novel object in novel object recognition task on the 11^th and 12^th days after CLP surgery (One-way ANOVA followed by multiple comparison tests, for each group); and (c) the performances of delayed matching-to-place (DMP) task in a water maze from the 13^th to 26^th days after CLP surgery. Greater latency and path length saving between trial 1 and trial 2 with intertrial intervals (ITI) of 5 sec, 20 min, or 2 h indicated better performance (two-way ANOVA followed by multiple comparison tests, for each group). The data were expressed as ; , , .Sham+NS: mice received laparotomy and tail vein injection of normal saline. Sham+MSC: mice received laparotomy and tail vein injection of MSCs; CLP + NS: mice received CLP surgery and tail vein injection of normal saline; CLP + MSC: mice received CLP surgery and tail vein injection of MSCs.

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