Edaravone Attenuated Particulate Matter-Induced Lung Inflammation by Inhibiting ROS-NF-κB Signaling Pathway

Figure 1

EDA attenuated PM-induced inflammation in HBECs. (a) HBECs were treated with EDA in a dose-dependent manner (300, 400, or 500 μM) and then stimulated with 300 μg/mL PM for 24 h. The mRNA expression of IL-6, IL-1α, and IL-1β was detected by RT-PCR. (b) The mRNA of COX-2 was detected by RT-PCR. (c) Western blot showed the expression of COX-2 in HBECs upon PM exposure after EDA treatment. The optical densities of COX-2 are shown in (d). Values are the ; , compared with the control group; ^# or ^##, compared with the PM group; . EDA: edaravone; PM: particulate matter; HBECs: human bronchial epithelial cells.

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